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It is possible, as the authors imply, that there might be some other anti-inflammatory benefits that are having an outcome on cancer risk reduction. Wolff-Sagy shared that future work would involve looking at other cohort studies, expanding the demographics and timeframe of the study, and digging into the molecular mechanisms behind GLP-1 treatments

It's crucial to be proactive and creative in finding solutions during this gap period

The weight change at one year post-discontinuation was small, but depended heavily on the individual and may partly reflect the fact that many patients resumed or transitioned to other weight-management therapies rather than remaining untreated

GLP-1 medications are peptide-based compounds with relatively high molecular weight and low lipid solubility

And this wasnt just a little weight loss

As is shown in Figure 2, when insulin binds to IR anchored on the surface of the PDA cell, insulin activates the PI3K-AKT signal pathway to upregulate the expression of mammalian target of rapamycin (mTOR) receptor through the crosstalk with G protein-coupled receptors (GPCR) (Shen et al., 2019)