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In fact, a recent scientific abstract described a case of life-threatening starvation ketoacidosis preceded by 5 days of nausea and vomiting that developed several weeks after starting tirzepatide for weight loss [33]
Bullous pemphigoid triggered by dulaglutide: A case report and a review of the literature

The primary mechanism of action involves binding to GLP-1 receptors located throughout the body, including the pancreas, brain, and gastrointestinal tract

Investigators compared patients with those treated with other systemic antidiabetic or antiobesity drugs for a follow-up period of 2 years

and for 20% it was 16.61, all versus placebo

Key Takeaway: The safety of combining these drugs depends heavily on your hydration status and kidney function
