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The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course

This article reviews clinical mechanisms, biomarker considerations, and how genetic factors may contextualize individual responses

Demonstrating sunken eyes and cheeks, a loss of mid-face volume, generalised skin laxity around the neck and jawline, an overall increase in signs of ageing, and more lines and wrinkles than you would expect for their date of birth

This fast-absorbing, non-greasy formula helps reduce shedding and keep the hair you have for longer

DPP-4 inhibitors were introduced for the treatment of type 2 diabetes in 2006

However, many primary care clinicians hesitate to initiate basal insulin due to concerns regarding time or effort needed to educate patients, doubts about patient acceptance or ability to manage titration or injection, or patient fears of hypoglycemia