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Experimental and clinical studies suggest that GLP-1 signalling may influence cytokine production, immune cell activation, and tissue inflammation ( In contrast, DPP-4isanother widely used incretin-based therapyhave been consistently associated with dermatologic adverse effects, particularly autoimmune blistering diseases such as bullous pemphigoid ( Although rare cutaneous adverse reactions to GLP-1 RAsincluding hypersensitivity reactions, eosinophilic panniculitis, bullous pemphigoid, and morbilliform drug eruptionshave been reported ( Unlike prior studies that focused on single dermatologic outcomes or non-comparative designs, the present study emulates a target trial to provide comprehensive, comparative dermatologic safety data for GLP-1 receptor agonists versus DPP-4 inhibitors across a broad spectrum of autoimmune and inflammatory skin diseases

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