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Studies in Chinese T2DM cohorts [37, 62] and the 16-week RCT by Kadouh et al

The gut microbiota is known to influence the enteroendocrine system[2] and modulate the host immune system through microbially derived metabolites or cellular membrane components[3]

Transdermal estradiol, delivered through patches or gels, bypasses hepatic first-pass metabolism and is associated with meaningfully lower thrombotic risk than oral estrogen formulations [18]

How the drugs work The drugs inhibit appetite and slow digestion, meaning people feel fuller for longer and eat less

Colonic delivery of -linolenic acid by an advanced nutrient delivery system prolongs glucagon-like peptide-1 secretion and inhibits food intake in mice

The dietary and lifestyle changes pathway do the same things without the expense of the drug