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Additionally, the same study reported a decrease in cigarette smoking among participants who were smokers, suggesting potential cross-substance benefits of GLP-1RAs in this population (Hendershot et al., 2025)

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These medications, once primarily diabetes drugs to manage blood glucose levels, now stand as backbone therapies for complex cardiometabolic conditions

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This mechanism also promotes osmotic diuresis, which helps lower blood pressure by approximately 4/2 mmHg and reduces fluid retentionproviding direct kidney benefits and kidney protection for patients with chronic kidney disease