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14 In PCa, hyperactive AR signaling supports cell growth, proliferation, and survival partly by reprogramming mitochondrial metabolism as well as by activating tumorigenic intracellular signaling cascades

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Participants losing at least 5% of body weight had markedly higher rates of steatohepatitis resolution than those losing less, and among the subset who lost at least 10%, essentially all had a reduction in activity score, roughly 90% achieved steatohepatitis resolution, and about 45% showed fibrosis regression