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Jacob Neil (Consultant Internal Medicine Wellkins Medical Centre) Glucagon-like peptide-1 (GLP-1) analogue therapy has revolutionized the management of Type 2 Diabetes and chronic weight management

Although GLP-1R expression in peripheral tissues is generally low and restricted to rare cell types (26), antiinflammatory benefits have been observed in various preclinical models, such as obesity, atherosclerosis, steatohepatitis, and nephritis, even in the absence of direct immune cell targeting (2732)

Participants receiving retatrutide lost an average of 11.5% and as much as 16.8% of their body weight after 40 weeks, far exceeding the placebo groups 2.6% reduction

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The mechanisms underlying the effect of GLP-1RAs on GI motility and symptoms like nausea and vomiting are summarized in Figure 1

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