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To further minimize any discomfort: Let the pen reach room temperature before injecting Ensure the alcohol is completely dry before inserting the needle Relax the muscle in the injection area Use a fresh needle every time Try taking some deep breaths before injecting if youre nervous When it comes to preparing for your first few injections, I usually remind my clients to stay hydrated, focus on fiber and protein, and ask a partner for help if they need support, says Sarah Logan, RD