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The lower-affinity cAMP-binding domain does not play any role in the cAMP-dependent disinhibition of Epac2 guanyl nucleotide exchange activity

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M., Kreymann B., Ghatei M

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Notably, cardiovascular events appear more frequently among certain AOM users

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Moreover, according to research by Ojima et al., a GIP concentration of 50 pM effectively suppressed the generation of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVECs) exposed to AGE

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Similar content being viewed by others Background The introduction of sodium-glucose co-transporter 2 inhibitors (SGLT-2i), glucagon-like peptide-1 receptor agonists (GLP-1RA), and dipeptidyl peptidase-4 inhibitors (DPP-4i) has significantly advanced therapeutic strategies for managing type 2 diabetes mellitus (DM), offering improved glycemic control and notable cardiovascular and renal benefits [1,2,3]

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