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For candidates on GLP-1s, a few specific factors come into focus

The majority of GLP-1R agonists, with a notable exception with exendin F1 ((46, 47), contribute to sustained cAMP generation from endosomes following internalization of the receptor-ligand complex (22, 23)

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(2004) 286:E6215

Gastrointestinal side effects observed under cotadutide effects are similar in quality but more severe than those under GLP-1RA treatment (52)

doi: 10.1016/S2213-8587(19)30194-9