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Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus

[DOI] [PubMed] [Google Scholar] 83.Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, et al

IH has received grants from AstraZeneca/Bristol Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen, Lexicon Pharmaceuticals, Medtronic, Merck & Co., Novo Nordisk, the Population Health Research Institute and Sanofi

This does not mean retatrutide is better or more suitable than existing licensed treatments

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes

The agreement centers on oral small-molecule GLP-1 receptor agonists, including YP05002, a next-generation candidate designed for chronic weight management and metabolic disorders