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Comparing the Chemical Designs of Semaglutide, Tirzepatide, and Retatrutide Peptides often face poor pharmacokinetics, making them susceptible to enzymatic degradation, renal clearance, and rapid receptor-mediated clearance

In one study, people without diabetes who took semaglutide (the active ingredient in Ozempic and Wegovy) were slightly more likely to be diagnosed with ED than those taking a placebo

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Ladage et al., 2013

Millennials were the most inclined to view GLP-1s as a "shortcut" weight loss method (77%) while Gen X was the most likely to reject this idea (33%)
