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The FDA approved it for diabetes management and later for weight loss, based on robust evidence from these studies

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GLP-1 receptors (GLP-1R) are G-protein coupled receptors predominantly located in pancreatic cells, which underpins their role in glucose homeostasis

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Nat Rev Endocrinol 12(6):357370

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However, patients who combine medication with structured diet, exercise, and behavioral habits show significantly better long-term outcomes

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Microdosing lowers medication exposure while the same receptor pathways remain active

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