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Users and observers alike reported overwhelmingly positive experiences, citing improvements in self-esteem (77%), social confidence (75%), and physical health (69%)

Its mechanism encompasses insulin resistance (IR), chronic inflammation, oxidative stress, mitochondrial dysfunction, and protein metabolism imbalance(see Figure 1)

10.14309/01.ajg.0000594772.87672.64 32 FernandezA

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doi: 10.1111/dom.14507 116 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al

doi: 10.1016/S0140-6736(10)60590-9