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Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned

Gourdy P, Darmon P, Dievart F, Halimi JM, Guerci B

Hanyaloglu A

The specific biomarkers focused on were adiponectin, leptin, IL-6, TNF-, plasminogen activator inhibitor-1 (PAI-1), brain natriuretic peptide (BNP), and high-sensitivity C-reactive protein (hs-CRP)

It highlights the ability of peripheral liraglutide to cross the BBB and specifically target hypothalamic ARC cells, eliciting significant appetite suppression and subsequent weight loss

Central administration of GLP-1 in rats and mice stimulates the HPA axis and increases secretion of corticosterone, and this is accompanied by increased cFOS immunoreactivity in CRH-positive neurons in the PVN [668,698,814]