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This signaling inhibition dampens T cell effector functions, including cytotoxicity and the production and secretion of IFN-, TNF-, and IL-2

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Besides, TIR is highly correlated with HbA1C, both of which have been currently recommended as major indicators to assess individual glycemic control [30]

doi:10.1002/j.1552-4604.1979.tb01646.x 221

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doi: 10.1016/j.peptides.2017.12.021
