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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus and chronic weight management

It reflects the fact that obesity has a physiological component that semaglutide was actively managing, and removing that management without a replacement strategy creates a gap

You may feel no immediate changes on day one

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In terms of weight management, the body tends to maintain a "set point" or a stable weight range

For comparisons between two groups at a single time point, an unpaired Students t-test was used