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Preventive investment will concentrate in clinical areas with high downstream ROI, rather than expanding broadly, as reimbursement tightens and evidence standards rise What the predictors say: Predictors are focused on the extent to which consumers are bypassing traditional care pathways, in favor of options that provide price transparency, higher-value care, simpler enrollment and intuitive digital tools that make it easier to navigate the healthcare system and access care directly

Part I: Epidemiology and Diagnosis Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee Diabetes & Metabolism Journal.2019

People taking either dose of resmetirom significantly lowered levels of the liver enzymes ALT, AST, and GGT, as well as sex hormone binding globulin, compared with placebo when figured either as percentage change or absolute reduction

Identify Areas for Clinical Differentiation To stand out clinically amidst increasing competition, manufacturers are moving beyond weight loss to explore expanding indications, novel clinical pathways, and additional therapeutic benefits