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The authors suggested that high dose Wegovy may increase the risk of reduced blood supply to the optic nerve through mechanisms involving blood pressure drops, fluid loss, and instability in the autonomic nervous system

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Semaglutide and tirzepatide achieve approximately 15-20% body weight reduction in clinical trials

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This produces a myriad of effects on metabolism pathways: Pancreatic and glycemic control [edit] Semaglutide enhances the growth and proliferation of pancreatic beta cells, which are responsible for insulin production, while mitigating oxidative stress to reduce cell death (apoptosis)

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The gut-brain-metabolism connection is real

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