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[81] confirmed a significant reduction in FIB-4 in diabetic patients treated with GLP-1 RAs, similar to those treated with SGLT2i

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Beyond that, using the thinnest needle that works for your situation, injecting slowly, and never forcing medication into tissue that feels resistant all protect long-term tissue health

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The phase 2b ENLIVEN trial, a multicenter, randomized, double-blind, placebo-controlled study, included 222 patients with biopsy-confirmed NASH and F2-F3 fibrosis, assigned to receive pegozafermin at doses of 15 mg weekly, 30 mg weekly, 44 mg every 2 weeks, or placebo for 24 weeks