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Tanaka M, Matsuo Y, Yamakage H, Masuda S, Terada Y, Muranaka K, et al

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When there is too much glucagon, the chances of high blood glucose levels are increased

HbA1C reduction was significantly greater with mazdutide compared to semaglutide
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So, the broader question is whether it is both clinically and economically better to aggressively treat certain high-risk obese patients sooner, or risk downstream cost and clinical complexity later
