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Description
New Engl J Med (2017) 377(1):1327
Half-Life and Duration of Action: Understanding medication duration is vital for effective treatment planning: Zepbounds extended half-life of 21 days may benefit those who prefer less frequent dosing
Unimolecular peptides with dual GIP/GLP-1 receptor agonism have been developed to improve metabolic efficacy and therapeutic index beyond what incretin mono-agonists can achieve (44, 63)
For tirzepatide, the equivalent range sits around 0.5 mg to 1.25 mg weekly
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