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This perspective article proposes a conceptual framework for consideration and research validation.

Note that you may also see the term: relapsing-progressive.As a helpful heuristic, we can think of relapsing-remitting disease as being secondary to demyelination and progressive disease as being caused by axonal damage.Clinically Isolated Syndrome Clinically isolated syndrome is a single clinical attack.Radiographically Isolated Syndrome Radiographically isolated syndrome refers to a situation wherein there are white matter lesions that fulfill certain diagnostic criteria for MS but there's no history of a clinical attack.In essence, this condition fulfills dissemination in space but not in time

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