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However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics

Nguyen H, Dufour R, Caldwell-Tarr A

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GLP-1 has different effects on left ventricular function and cardiac contractility under healthy vs

An injection is given once weekly Rybelsus- tablet given once daily Exenatide: It is sold as Byetta is injected twice daily Bydureon injected once a week Liraglutide: the available brands are Victoza is used to treat Type 2 DM Saxenda used to manage chronic weight management Dulaglutide: It is marketed as Trulicity

To gain deeper insights into the impact of the conjugate on both the brainstem and the mesolimbic reward system, we conducted complementary transcriptomics analyses (Extended Data Fig