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This was followed by the observation that GIP could also stimulate insulin secretion in animals and humans, and thus, it was later renamed as glucose-dependent insulinotropic polypeptide, while retaining the same acronym (Dupre et al., 1973

In skeletally mature female rats, moderate energy restriction over 12 weeks had minimal negative effects on bone, but severe restriction significantly reduced bone mass and levels of IGF-1, leptin, and estradiol

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