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In the next five to seven years, for sure, [Novo Nordisk] will face some difficulties in retaining its market share, says Karan Verma, a healthcare research analyst at information services provider Clarivate

NICE Technology Appraisal 875 recommends semaglutide 2.4 mg (Wegovy) as an option for weight management in adults with a BMI of at least 35 kg/m (or 32.5 kg/m in certain ethnic groups) and at least one weight-related comorbidity

Common violations include poor manufacturing practices, false product claims, selling misbranded items, or marketing unapproved products

NHS Talking Therapies accepts self-referral in most areas of England

The standard dose escalation schedule gradually increases doses to minimize side effects, but the first 8-16 weeks typically require the most vigilant hydration and prevention efforts

the initial weeks of dose escalation significantly reduce the severity and duration of GI side effects at the full therapeutic dose