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Advise patients that changes in insulin regimen can predispose to hyperglycemia or hypoglycemia and that changes in insulin regimen should be made under close medical supervision [see Warnings and Precautions (5.2)]

any such changes are more likely related to weight loss, hormonal shifts, or psychological factors

The manufacturer (Novo Nordisk) subsequently completed additional clinical trials using semaglutide at a slightly higher weekly dose, but the trial was designed for weight loss instead of diabetes

The most commonly reported adverse effects were gastrointestinal nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class and generally dose-dependent

However, as your testosterone levels rise and your energy increases, you may start noticing the gradual effects of weight loss

Then draw back your desired volume