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The 45.3% figure nearly half of all patients losing 30% of their body weight is unprecedented in obesity pharmacotherapy

This trend is of particular relevance to anaesthesiologists, given the emerging evidence of potential adverse effects associated with these medications

Retail cost: Without insurance, IBSC treatments like Linzess and Ibsrela can be expensive in the United States

Upon analysis, results suggested the placebo-adjusted systolic blood pressure changes from baseline were 7.4 (95% CI, 10.0 to 4.7) mmHg, 10.6 (95% CI, 13.2 to 8.0) mmHg , and 8.0 (95% CI, 10.6 to 5.4) mmHg for tirzepatide 5, 10, and 15 mg, respectively

Caution in patients with history of pancreatitis

Diarrhoea: Ensure you stay hydrated