![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.
Description
R., Barbieri, M., Marfella, R
![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://www.researchgate.net/publication/371461642/figure/fig2/AS:11431281210340311@1702043944953/Mechanisms-of-action-of-GLP-1RA.jpg)
Semaglutide sold as Wegovy is currently the most commonly prescribed GLP-1 medication for managing obesity
![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://em.huatengsci.com/upload/202304/23/202304231920227793.png)
GLP-1 RA use was identified as an independent risk factor for food retention (OR 9.19, p = 0.0003)
![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://www.frontiersin.org/files/Articles/1085799/xml-images/fendo-14-1085799-g001.webp)
GLP-1Rs are expressed in the hypothalamus, hippocampus, cortex, and brainstem, as well as limbic and reward-related circuits (47)
![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://www.mdpi.com/diseases/diseases-13-00127/article_deploy/html/images/diseases-13-00127-g001.png)
Once released, GLP-1 acts to increase insulin secretion from beta cells in the pancreas which helps lower blood glucose levels
![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://www.nutritional-psychology.org/wp-content/uploads/2025/12/Figure-1.jpg)
doi:10.1016/j.cmet.2017.07.011 44
![glp 1 receptor agonists mechanism of action of GLP-1 [25] Mechanisms of action of GLP-1RA.](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrendo.2012.140/MediaObjects/41574_2012_Article_BFnrendo2012140_Fig1_HTML.jpg)
