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Between 3 and 5 million Americans use the herbal supplement, either recreationally or to self-manage medical conditions such as pain or insomnia, according to pro-kratom advocacy group the American Kratom Association.

In an update posted on its website on 2 January 2024, the US FDA confirmed that it was carrying out the []

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While the absolute risk increase was modest, our findings point to an important potential adverse effect that clinicians should consider, especially in patients with predisposing factors for GERD

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