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The dose is gradually increased over 5-8 weeks until the maintenance dose is reached

Today, were talking about how the rapid rise in the use of GLP-1 marks a shift in the treatment landscape for obesity care and why nutrition is central to supporting patients on weight-loss medications

From this perspective, GLP-1-RAs appear as a safe treatment option

VNR, value not reported

Many studies have found no significant changes in basal or stimulated cortisol levels with GLP-1 therapy

An optogenetic stimulation of GLP-1Rs in habenular circuits was also shown to abolish nicotine reward and decrease nicotine intake in mice 109