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GLP-1R agonists effects on cardiovascular events The first pieces of evidence of the potential clinical benefit of GLP-1 agonists have emerged recently, pointing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and revascularization procedures

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However, it is still unclear whether this affects the incidence of pancreatic cancer (40, 41)

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In diabetic mice, D13 and D41 demonstrated prolonged hypoglycemic effects