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Additionally, GLP-1 receptor agonists have demonstrated dual benefits in reducing headache symptoms and promoting weight loss in patients with idiopathic intracranial hypertension, offering therapeutic advantages for conditions involving both metabolic dysregulation and chronic pain 63

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Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO (37)

The expected timeline for patent expiration: The long patent timelines reflect layered intellectual property: composition-of-matter patents, formulation patents, manufacturing process patents, and dosing regimen patents

3.5 Skin side effects Injection site reactions, such as rash, erythema, or itching at the injection site, are common with GLP-1 receptor agonists ( Table 5 , in the Appendix)