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Studies showed that GLP-1 receptor agonists like semaglutide are associated with a high proportion of lean muscle loss, which can range from 25% to 40% of the total weight reduction in patients with obesity

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The mechanisms by which GLP-1 RAs induce weight loss are multifaceted and are linked to GLP-1R activation in both central and peripheral enteric neurons, slowing gastric emptying and intestinal transit, as well as suppressing appetite at the hypothalamus level, collectively influencing a mechanism known as the ileal brake