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The results of this and similar studies, most of which have only been reported as abstracts, are summarized in Fig
Considering the beneficial effects of GcgR antagonists on glycaemia [66,67,68], it would seem counterintuitive to employ agonism in a therapy for obesity and, certainly, diabetes
Studies have found that people with overweight or obesity may have a reduction in incretin effects, particularly if they have had frequent weight fluctuations due to yo-yo dieting

This allows the stimulant and thermogenic effects to align with daily activity levels

The New Biology and Pharmacology of Glucagon

See also Supplemental Figure 5
