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As of March 2026, a higher dose of 7.2 mg per week has been approved for eligible patients in the U.S

Phentermine and topiramate extended-release 22.5 mg/138 mg [a supra-therapeutic dose resulting in a phentermine and topiramate maximum concentration (Cmax) of 4-and 3-times higher than those at phentermine and topiramate extended-release 7.5 mg/46 mg, respectively] did not affect cardiac repolarization as measured by the change from baseline in QTc

Ensure proper hydration and monitor kidney function metrics if gastrointestinal symptoms become severe during the initiation phase

Our team in Central Austin, TX, can be reached at (512) 561-0971

Telehealth providers like Klarity can help evaluate your eligibility and navigate savings options

The MTHFR Connection: Why Methylation Status Matters Here If you've already had MTHFR testing or you're here because you searched "MTHFR and semaglutide" here's the honest answer about what that connection looks like