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Importantly, efpeglenatides immunogenicity remained relatively low, with few patients developing clinically significant anti-drug antibodies, allowing its safety profile to be viewed as manageable within class expectations

Common side effects include: Gastrointestinal Issues - This is the most common side effect, including constipation, cramps, diarrhea, nausea, vomiting, heartburn, and belching Fatigue Dizziness Allergic reactions, such as itching or rashes Injection site reactions (redness, swelling) Rare and more serious side effects can include: Pancreatitis Gallbladder issues Thyroid tumours Kidney problems Severe allergic reactions such as difficulty breathing and swelling of the face, lips, or throat Diabetic retinopathy Severe changes in mood or behaviour Please note that the more serious side effects are very rare

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It may also make adhering to other healthy habits like exercising more difficult

The STEP 1 trial showed average weight loss of 14.9% over 68 weeks

Current Molecular Pharmacology