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In the first clinical trial of its kind, people taking semaglutide drank less alcohol, adding to its promise of fighting addiction.

A comprehensive review of the literature was conducted to examine the etiology of HFpEF, the role of endothelial dysfunction, and the effects of GLP-1R agonists on endothelial function and heart failure outcomes

Nearly half asked questions about personalizing compounded GLP-1RAs to justify continued compounding outside of a drug shortage. Continued below...

Boris Johnson has chosen an unconventional issue to write about for his first column.

For those who want to go deeper: JAMA Psychiatry (2025):- GLP-1 RAs & Mental Health Meta-Analysis: JAMA Psychiatry (2025):- Semaglutide & Alcohol Use Disorder RCT: eClinicalMedicine / The Lancet (2024):- 12-Month Neurological & Psychiatric Outcomes of Semaglutide: APA Monitor (2025):- Mental Health Effects of GLP-1 Drugs (accessible overview):

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