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Experts note that many patients discontinue the use of weight-loss medications due to side effects

Key factors to consider include: Approved uses : Many GLP-1s are approved for managing Type 2 diabetes, while others are approved for weight loss

Garber, A

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Clinical trials have demonstrated that GLP-1 receptor agonists produce substantial reductions in total body weight, with emerging evidence suggesting effects on visceral adipose tissuethe metabolically active fat stored around abdominal organs

Addressing these challenges through rational design, safety-by-design protocols, and translational trial frameworks will be crucial for realizing the long-term clinical impact of GLP-1R-targeted gene and protein therapies