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this regimen was modeled after NIH protocols using rituximab, cyclophosphamide, and corticosteroids ( Available literature supports that TBIR, although rare, is potentially reversible with prompt diagnosis and aggressive immunotherapy tailored to comorbid autoimmune conditions ( Management strategies can vary, as demonstrated by a case treated successfully with low-dose immunosuppressive therapy, indicating that less intensive treatment regimens combining corticosteroids and immunomodulatory agents may lead to gradual clinical improvement, decreased insulin requirements, and disappearance of insulin receptor autoantibodies

However, the degree to which GLP-1 and other gut peptides are responsible for the metabolic successes after bariatric surgery is continually debated

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The drugs effects on weight loss [10,13] and insulin sensitivity [27] further contribute to reduced hepatic fat accumulation and inflammation

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