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Conversely, in chronic treated patients the effects on volume changes are slightly reduced because a new steady state is reached, due to a counter-regulatory effect, resulting in a lower total body sodium concentration and blood volume (53)

Furthermore, Jensterle et al.in another study demonstrated that liraglutide 3.0 mg/day was more effective in reducing BMI and WC in PCOS patients with obesity than the combination of metformin 1000 mg BID + liraglutide at low doses (1.2 mg/day), that has hitherto been considered one of the more promising treatment [63]

In the landmark SURMOUNT trials , participants using the highest dose of tirzepatide (15 mg) achieved an average weight loss of approximately 2022% of their initial body weight over 72 weeks

These mechanisms typically self-resolve as your body adapts to the new metabolic steady state

Disrupted ovulation The hormonal imbalances in PCOS can disrupt the normal ovulation process, leading to the formation of small cysts on the ovaries

While these drugs offer impressive results for weight loss and blood sugar control, growing evidence suggests they may come with concerning long-term effects that arent always discussed in the consultation room