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Patients with obesity have approximately two to three times the risk of developing blood clots compared to individuals with normal weight

Tchernof A, Poehlman ET

Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain

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A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation

Factors such as baseline body composition, pre-existing thyroid function, nutritional status, and environmental temperature all influence whether a patient experiences cold sensitivity