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Metabolic and cardiometabolic markers that may reflect the drug's activity include: Fasting blood glucose and HbA1c (particularly relevant in type 2 diabetes) Lipid profile (total cholesterol, LDL, triglycerides) Blood pressure Waist circumference Liver function tests, particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD, previously termed NAFLD)

Licensed injectable GLP-1 medications available through the NHS include: Semaglutide (Ozempic for diabetes

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Our study demonstrates that effective weight loss is possible at doses of GLP1a that are lower than previously reported

Dose adjustments may be necessary

There was an overall stroke risk reduction of 17% with GLP-1 RAs across the trials ( p = 0.0002) [13], with significant reductions in the risk of both stroke overall and ischaemic stroke (both 17%) [14]