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Strategy Every case is unique, which means each strategy is also unique and highly customized

While GLP-1 (7-36amide) and GLP-1 (737) are equally potent to stimulate the secretion of insulin and c-peptide [181], GLP-1 (137) has a much lower insulinotropic efficacy [[80], [81], [82]]

As a glucagon-like peptide-1 receptor agonist, Ozempic improves insulin sensitivity through appetite suppression and weight loss

However, both medications can cause gastrointestinal side effects that may be more pronounced when used together, requiring medical monitoring

In addition, first oral GLP-1 receptor agonist (oral semaglutide) was recently approved ( Table 1

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