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Human studies have shown these medications are safe, and even protective when patients are followed for up to 5 years.163 GIP GIP acts in synergy with GLP-1 to regulate postprandial insulin secretion.164 The effect of GIP agonism in obesity is most significant when combined with GLP-1 agonism

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[DOI] [PubMed] [Google Scholar] 58.Becerra-Tomas N., Blanco Mejia S., Viguiliouk E., Khan T., Kendall C.W.C., Kahleova H., et al