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A bit of history: It was one of the first GLP-1 drugs ever approved and laid the foundation for everything that came after

For instance, patients with hepatic impairment do not require dosage adjustments, while those with renal impairment should be cautious due to the risk of dehydration and acute kidney injury

To microdose safely, doctors say, pay attention to the shelf life of opened pens, store them properly, and use a new needle with each injection

Splitting doses may help reduce nausea, bloating, fatigue, appetite crashes, and medication wear-off symptoms in select patients

The FDA-approved injection sites for tirzepatide include the upper arm, upper thigh, and abdomen

Another important way to contain costs is to make sure patients who seek insurance coverage for GLP-1 drugs actually need them