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From payer friction to behavioral drop-off, GLP-1s are challenging pharma to rethink how success is measured in the obesity and diabetes markets

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However, because federal law does not require state-licensed pharmacies that are not outsourcing facilities to submit adverse events to FDA, many cases are likely going undocumented.FDA has also warned companies that have illegally sold unapproved drugs containing semaglutide, tirzepatide or retatrutide that are falsely labeled for research purposes or not for human consumption. These products have been sold directly to consumers for human use with dosing instructions

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Methods A systematic review was conducted following PRISMA 2020 guidelines (PROSPERO: CRD420261305875)