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Tirzepatide appears to produce greater reductions in lean mass than most other therapies, while semaglutide also results in significant muscle loss

38% say they used the medications only to lose weight

On January 4, 2026 , Novo Nordisks data exclusivity for semaglutide in Canada also expired the second layer of protection that had been running concurrently with the lapsed patent, and the one that had been preventing generic manufacturers from relying on Novos regulatory data to file their own submissions

Healthcare providers design treatment schedules around published clinical trial data, and biweekly dosing lacks this evidence base for safety and efficacy

Patients with different body types may require adjustments to ensure the medication is delivered to the intended subcutaneous tissue