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Mechanistically, GLP-1 signaling suppresses M1-associated genes while enhancing that of M2-related genes through activation of signal transducer and activator of transcription 3 (STAT3) (Wan and Sun, 2019)
Further, significantly fewer people discontinued treatment with Trulicity compared to semaglutide or exenatide.1 Trulicity versus injectable semaglutide: Persistence: 143.6 days (Trulicity) versus 129.9 days (semaglutide)

Clinical Development Status Its crucial to understand that triple-agonist medications are not yet FDA-approved
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At 5 mg/mL concentration, 50 units delivers 2.5 mg, which slightly exceeds the standard 2.4 mg maximum
